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Fishing for Answers in Human Disease
Caption: Researcher Zhaoxia Sun, at Yale, uses the zebrafish to study Polycystic Kidney Disease, which affects more than 600,000 Americans. Mutations in the zebrafish vhnf1 gene, and its human...
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Cool Videos: Diving for Drugs
Who says biomedical scientists always have to work indoors? The next installment in our mini-film fest proves otherwise, offering a close-up look at some medicinal chemists who are busy carrying out...
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Alzheimer’s-in-a-Dish: New Tool for Drug Discovery
Caption: A plaque (orange) disrupts the normal network of human neurons (green) grown in a three-dimensional gel in the lab, mimicking the brain anatomy of Alzheimer’s patients.Credit: Doo Yeon Kim and...
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Digging Up New Antibiotics
Caption: Microfluidic chip being used by scientists to search dirt for new sources of antibiotics.Credit: Slava Epstein/Northeastern U. Last fall, President Obama issued an Executive Order aimed at...
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Got It Down Cold: Cryo-Electron Microscopy Named Method of the Year
Caption: Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. Credit: Veronica...
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DNA Barcodes Could Streamline Search for New Drugs to Combat Cancer
A little more than a decade ago, researchers began adapting a familiar commercial concept to genomics: the barcode. Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we...
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Fighting Depression: Ketamine Metabolite May Offer Benefits Without the Risks
Thinkstock/Ryan McVay For people struggling with severe depression, antidepressants have the potential to provide much-needed relief, but they often take weeks to work. That’s why there is growing...
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Creative Minds: Breaking Size Barriers in Cryo-Electron Microscopy
Dmitry Lyumkis When Dmitry Lyumkis headed off to graduate school at The Scripps Research Institute, La Jolla, CA, he had thoughts of becoming a synthetic chemist. But he soon found his calling in a...
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Fighting Parasitic Infections: Promise in Cyclic Peptides
Caption: Cyclic peptide (middle) binds to iPGM (blue). Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind...
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Deciphering Another Secret of Life
Credit: Robin Davies, University of Wisconsin-Madison In 1953, Francis Crick famously told the surprised customers at the Eagle and Child pub in London that he and Jim Watson had discovered the secret...
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Speeding COVID-19 Drug Discovery with Quantum Dots
Credit: Ethan Tyler and Alan Hoofring/NIH Medical Arts These round, multi-colored orbs in the illustration above may resemble SARS-CoV-2, the coronavirus responsible for COVID-19. But they’re actually...
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Using AI to Find New Antibiotics Still a Work in Progress
Each year, more than 2.8 million people in the United States develop bacterial infections that don’t respond to treatment and sometimes turn life-threatening [1]. Their infections are...
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